The CTC1-STN1-TEN1 (CST) complex is a single-strand DNA-binding protein complex that plays an important role in genome maintenance in King Mattress various model eukaryotes.Dysfunction of CST is the underlying cause of the rare genetic disorder known as Coats plus disease.In addition, down regulation of STN1 promotes colorectal cancer development i
Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione
Abstract Background Increased airway epithelial proliferation is frequently observed in smokers.To elucidate the molecular mechanisms leading to these epithelial changes, we studied the effect of cigarette smoke condensate (CSC) on cell proliferation, wound closure and mitogen activated protein kinase (MAPK) activation.We also studied whether modul
Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient
Purpose.The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported.Summary.The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close monitoring for potential drug-drug interactions.The patient, a 57-year-old Caucasian male kidney transpl
The radial distribution function reveals the underlying mesostructure of the AdS black hole
Abstract Based on the equations of state, one can infer the underlying interaction potentials among the black hole molecules in the case of Schwarzschild-AdS and charged AdS black holes.The microscopic molecules with the interaction potential arrange in a specific way to form the mesostructure, whose size is between the macro (black hole system) an